Indikation
Behandling av klimakteriebesvär postmenopausalt
Motivering
Kombinerad kontinuerlig lågdosbehandling med god symtomlindring för kvinnor med klimakteriella besvär som önskar blödningsfrihet.
Utredningsmaterial och referenser
- Schierbeck LL, Rejnmark L, Tofteng CL, Stilgren L, Eiken P, Mosekilde L, Køber L, Jensen JE. Effect of hormone replacement therapy on cardiovascular events in recently postmenopausalwomen: randomised trial. BMJ. 2012;345:e6409. PubMed
- Boardman HMP, Hartley L, Eisinga A, Main C, Roqué i Figuls M, Bonfill Cosp X et al. Hormone therapy for preventing cardiovascular disease in both healthy post-menopausal women and post-menopausal women with pre-existing cardiovascular disease. Cochrane Database Syst Rev. 2015 Mar 10;3:CD002229. PubMed
- Baber RJ, Panay N, Fenton A; The IMS Writing Group. Recommendations on women’s midlife health and menopause hormone therapy. Climacteric. 2016;19:109-50. PubMed
- Hodis HN, Mack WJ, Henderson VW, Shoupe D, Budoff MJ, Hwangf et al for the ELITE Research Group. Vascular Effects of Early versus Late Postmenopausal Treatment with Estradiol. N Engl J Med. 2016;374:1221-31. PubMed
- Sjögren LL, Mørch LS, Løkkegaard E. Hormone replacement therapy and the risk of endometrial cancer: A systematic review. Maturitas. 2016;91:25–35. PubMed
Bedömning utförd av
Expertrådet för obstetrik och gynekologi
